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Metronidazole has shown proof of carcinogenic action in a number of reports involving chronic oral administration in mice and rats. Outstanding amongst the results inside the mouse was the advertising of pulmonary tumorigenesis. This continues to be observed in all six reported scientific studies in that species, which includes one particular analyze wherein the animals ended up dosed on an intermittent agenda (administration in the course of each individual fourth week only). At incredibly superior dose concentrations (somewhere around 500 mg/kg/day), there was a statistically sizeable rise in the incidence of malignant liver tumors in males.
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METROGEL-VAGINAL affords negligible peak serum concentrations and systemic publicity (AUCs) of metronidazole in comparison to five hundred mg oral metro‑nidazole dosing. Despite the fact that these decrease amounts of publicity are less likely to provide the popular reactions witnessed with oral metronidazole, the opportunity of these together with other reactions can not be excluded presently.
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